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title Systems biology in vaccine design (Invited review)
Authors Six, A., B. Bellier, V. Thomas-Vaslin, and D. Klatzmann
Source Microbial Biotechnology. vol 5 issue2 pages 295–304
Year 2012
Type Journal
Type of publication ISC-PIF scholar

Optional Infos

Abstract Vaccines are the most effective tools to prevent infectious
diseases and to minimize their impact on
humans or animals. Despite the successful development
of vaccines that are able to elicit potent and
protective immune responses, the majority of vaccines
have been so far developed empirically and
mechanistic events leading to protective immune
responses are often poorly understood. This hampers
the development of new prophylactic as well as therapeutic
vaccines for infectious diseases and cancer.
Biological correlates of immune-mediated protection
are currently based on standard readout such as
antibody titres and ELISPOT assays. The development
of successful vaccines for difficult settings,
such as infectious agents leading to chronic infection
(HIV, HCV. . .) or cancer, calls for novel ‘readout
systems’ or ‘correlates’ of immune-mediated protection
that would reliably predict immune responses to
novel vaccines in vivo. Systems biology offers a new
approach to vaccine design that is based upon understanding
the molecular network mobilized by vaccination.
Systems vaccinology approaches investigate
more global correlates of successful vaccination,
beyond the specific immune response to the antigens
administered, providing new methods for measuring
early vaccine efficacy and ultimately generating
hypotheses for understanding the mechanisms that
underlie successful immunogenicity. Using functional
genomics, specific molecular signatures of individual
vaccine can be identified and used as predictors of
vaccination efficiency. The immune response to vaccination
involves the coordinated induction of master
transcription factors that leads to the development
of a broad, polyfunctional and persistent immune
response integrating all effector cells of the immune
Link http://onlinelibrary.wiley.com/doi/10.1111/j.1751-7915.2011.00321.x/abstract;jsessionid=772BD05562B3376458928CB3890F68FF.d04t01?deniedAccessCustomisedMessage=&userIsAuthenticated=false
Created Monday 12 November, 2012 14:42:53

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